If you zero at 50 YARDS, not meters.. it should keep you within 2" point of aim from 8 meters to 220 meters.
So if your sights are not on the same plane... you need to figure out how much the smaller apeture changes things. Perhaps emailing the company to ask them. They may even tell you what distance to sight in at to achieve the results expected from their sight.
From what I have read.. if you have a small and large apeture.. if the large one is setup at the 50 yards.. then it should cover you pretty well out to about 250 meters.. granted at 250 you're going to be probably 4" low. Then the smaller apeture should cover you to around 300 meters.
Looking at a ballistics chart for the ammo I have, at a 100 yard zero it's showing it dropping 2.7 inches at 200 yards, 10.9 inches at 300 yards. It's also showing it being -0.3 inches at 50 yards.
I have my buis sighted in fairly decent at 50 yards.. at 300 meters.. mine is a same plane version.. I was hitting a 12" steel plate by just holding above the target a few inches.
I think the best thing you can do, is contact the company and ask them about the sight. If it is a dual plane sight, you'll want it setup good. Like I said, everything I read says the best thing to do is sight in at 50 yards. Heck, many military sight in at only 25 yards and just make sure the bullet impace is slightly lower than the point of aim. But if you're wanting 250m with the large apeture, then 300+ with the smaller one.. I think you should ask them how they recommend zeroing it. Theirs may be a 250 and 300-400 sight.. who knows. if mine wasn't a same plane, it'd be a 250 and 300 apeture.